Percocet is a prescription opioid pain reliever that combines oxycodone, a powerful opioid, with acetaminophen (also known as paracetamol), a non-opioid pain reliever and fever reducer.(Source) Oxycodone is a semisynthetic opioid made from thebaine, a substance derived from the opium poppy.(Source)

Acetaminophen is commonly found in over-the-counter medications like Tylenol and helps relieve mild to moderate pain and reduce fever.(Source) In Percocet, acetaminophen works together with oxycodone to increase pain relief, but it also adds its own risks, including potential liver damage at high doses.(Source)

When taken as prescribed, Percocet is typically used for short-term relief of moderate to severe pain, such as after surgery, injury, or certain medical procedures.(Source) Oxycodone in Percocet binds to opioid receptors in the brain and spinal cord, reducing the perception of pain and triggering the release of dopamine, a neurotransmitter associated with pleasure and reward.(Source)

This dopamine surge can create feelings of euphoria, relaxation, and well-being. Over time, the brain can begin to rely on Percocet to feel “normal,” which is one reason why this medication is so addictive.(Source) Even people who start Percocet with a legitimate prescription can develop tolerance, dependence, and, in some cases, opioid use disorder (OUD).