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Gabapentin: Withdrawal Symptoms, Side Effects, and Abuse Risks

Gabapentin (brand name Neurontin) is a prescription medication used to treat seizures and certain types of nerve pain. When taken exactly as prescribed, it can be safe and effective. However, gabapentin is increasingly misused, combined with other substances, and bought or sold illegally, which can lead to dependence, withdrawal symptoms, and serious health risks.(Source) If you or someone you love is using gabapentin in higher doses than prescribed or without a prescription, professional support can make a critical difference.

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What Is Gabapentin?

Gabapentin is an oral prescription medication available as capsules, tablets, and oral solutions. The generic name is gabapentin, and common brand names include Neurontin, Gralise, and Horizant.(Source)

Gabapentin is structurally related to gamma-aminobutyric acid (GABA), a neurotransmitter that helps calm activity in the brain. However, gabapentin does not bind directly to GABA receptors. Instead, it attaches to specific calcium channels in the central nervous system, which helps reduce abnormal electrical activity and decrease certain types of nerve pain.(Source)

Gabapentin is not an opioid and is not a benzodiazepine, but it can still affect mood, coordination, and alertness. Because of these effects, it has become a drug of misuse in some communities, especially when combined with opioids, alcohol, or other sedating medications.(Source)

Gabapentin is only legally available with a prescription from a licensed medical provider. Despite this, it is widely diverted and sold on the street under names like “gabbies” or “johnnies.”(Source)

Frequently Asked Questions

Gabapentin does not produce the same intense euphoria as many opioids or stimulants, but it can still be misused and can lead to physical dependence and withdrawal symptoms, especially at high doses or when combined with other substances.(Source) People with a history of substance use disorders appear to be at higher risk for misusing gabapentin. If you notice cravings, escalating doses, or withdrawal symptoms when you miss a dose, it is important to speak with a medical professional or treatment provider.

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